Homocysteine levels in autism spectrum disorder: A clinical update.
Endocr Metab Immune Disord Drug Targets. 2018 Feb 12;:
Authors: Fuentes-Albero M, Cauli O
Homocysteine (Hcy) is a non-protein α-amino acid, which plays several important roles in human physiology and in the central nervous system. Although Hcy has several known biological properties in one-carbon metabolism, its overproduction might be harmful and could add to the pathophysiology associated with autism spectrum disorder (ASD). This review presents updated information about alterations in the concentration of this amino acid in biological fluids (blood and urine) in patients with ASD. In addition, we assessed its clinical significance by analyzing if there are any potential associations between abnormal Hcy levels and the severity ASD or any of its symptoms. Further research is still needed to correlate the occurrence of increased Hcy levels with specific symptoms/deficits in ASD and to evaluate the clinical impact on ASD of strategies that can reduce the Hcy concentration.
PMID: 29437021 [PubMed – as supplied by publisher]