Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Related Articles

Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Biomark Med. 2017 Jul;11(7):547-556

Authors: Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT

Abstract
AIM: We compared three statistical methods in selecting a panel of serum lipid biomarkers for mesothelioma and asbestos exposure.
MATERIALS & METHODS: Serum samples from mesothelioma, asbestos-exposed subjects and controls (40 per group) were analyzed. Three variable selection methods were considered: top-ranked predictors from univariate model, stepwise and least absolute shrinkage and selection operator. Crossed-validated area under the receiver operating characteristic curve was used to compare the prediction performance.
RESULTS: Lipids with high crossed-validated area under the curve were identified. Lipid with mass-to-charge ratio of 372.31 was selected by all three methods comparing mesothelioma versus control. Lipids with mass-to-charge ratio of 1464.80 and 329.21 were selected by two models for asbestos exposure versus control.
CONCLUSION: Different methods selected a similar set of serum lipids. Combining candidate biomarkers can improve prediction.

PMID: 28534416 [PubMed – indexed for MEDLINE]

Facebook Comments

Autism Chat

%d bloggers like this: