Clinical associations of maternal thyroid function with fetal brain development:Epidemiological interpretation and overview of available evidence.

Clin Endocrinol (Oxf). 2018 Apr 24;:

Authors: Korevaar TIM, Tiemeier H, Peeters RP

TH is an important regulator of metabolism, growth and development in practically all tissues of the human body. During pregnancy, major changes occur in thyroid physiology including an increase in TH binding globulins, an increase in TH degradation by thyroid degrading enzymes (due to placental expression of type 3 deiodinase) and an increase in thyroid stimulation through high concentrations of human chorionic gonadotropin (hCG). Both overt hypothyroidism and Graves’ hyperthyroidism, which occur in approximately 0.3% and 0.05% of all pregnant women, are well-known modifiable risk factor for a wide range of adverse pregnancy and child outcomes. This article is protected by copyright. All rights reserved.

PMID: 29693263 [PubMed – as supplied by publisher]

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